The word "most assistant" pertains to someone who is very helpful or supportive. However, its antonyms refer to those who are uncooperative, unhelpful, or unfriendly. Some of the antonyms of "most assistant" include obstinate, unyielding, unaccommodating, obstructive, difficult, hostile, and unresponsive. These words depict those who are not willing to lend a hand, hinder progress, or create conflict. When dealing with people or situations, it is essential to identify the antonyms of "most assistant" to avoid any setbacks or difficulties. Understanding their meanings and implications can help you choose the right words to convey your message accurately and appropriately.