The antonyms for "most close-at-hand" are distant, faraway, remote, inaccessible, and out-of-the-way. These words indicate that something is not nearby or readily available. For example, a remote area cannot be reached easily, while an inaccessible place is not open to the public. Faraway refers to a place that is a long distance away, and out-of-the-way suggests that something is off the beaten path. These antonyms are useful for describing the opposite of something that is close-at-hand, such as a distant object, remote location, or inaccessible resource. A thorough understanding of these words can help one effectively communicate the opposite of something that is "most close-at-hand".