The word "most defiling" implies something that is extremely damaging or corrupting. Its antonyms include "pure," "clean," "wholesome," "innocent," "virtuous," and "healing." These words are associated with positivity and goodness, unlike "most defiling," which is linked to negativity and destruction. To describe something that is in opposition to "most defiling," one could use these antonyms to paint a picture of hope, restoration, and recovery. By using the antonyms in a sentence, one can convey a clear and powerful message that will create a lasting impression on the listener or reader.