Most endwise refers to the position of something being located on or near the end of something else. Synonyms for this phrase might include words like terminal, extremity, or tip. Another possible synonym is the word "terminus," which refers specifically to the final point of a transportation route, such as the last stop on a train line. Other words that might be used in place of most endwise include ultimate, concluding, or final. These words all convey a sense of being at or near the end of something, whether it's a physical object or an abstract concept like a process or a story.