Antonyms for the phrase "most little known" would include "popular," "famous," "well-known," "common," "mainstream," "recognized," "established," "prominent," and "visible." These words highlight the opposite meaning of "most little known," which suggests something that is largely unknown or obscure. By contrast, the antonyms imply a degree of familiarity or public recognition. For example, a "popular" restaurant is one that is well-known and attracts many customers, whereas a "little-known" restaurant is one that is less familiar and might not draw much attention. Considering antonyms can help to clarify the intended meaning of a word or phrase and broaden our understanding of language usage.