Most pee-wee is a phrase used to describe something that is very small or insignificant. Some antonyms for this phrase could include big, mighty, grand, huge, or significant. Opposing words to pee-wee include substantial, considerable, massive, and important. While pee-wee is often used in a lighthearted or humorous context, it can also imply weakness or lack of significance. The opposite terms contradict this idea and suggest strength, power, grandeur, or importance. Choosing the right antonym depends on the specific context and message you want to convey.