The phrase "most really-truly" is an informal way of emphasizing something that is true or genuine. Other synonyms for this phrase include "absolutely," "truly," "genuinely," "positively," and "undoubtedly." These synonyms can be used interchangeably to convey the same level of emphasis and sincerity. For example, "I most really-truly appreciate your help" could be rephrased as "I absolutely appreciate your help" or "I genuinely appreciate your help." These synonyms can help add emphasis to statements and convey a sense of sincerity and authenticity. It is important to choose the right synonym to best convey the intended meaning and tone.