Most saddled refers to something or someone that is burdened or weighed down by responsibilities, troubles or difficulties. There are many synonyms that convey similar meanings of this expression. Some examples of such words are overwhelmed, bogged down, encumbered, bogged down, burdened, loaded, oppressed, and troubled. These terms are often used to describe the feeling of being overly encumbered by different factors in one's life. From financial difficulties to emotional problems, these synonyms aptly describe the feeling of being most saddled and can be used interchangeably to convey a similar meaning.