Most toilful refers to something that involves a lot of hard work and effort. Its antonyms include terms that describe things that are easy, effortless, and simple. The opposite of most toilful might be something enjoyable, such as a leisurely activity or an activity that doesn't require much effort. It could also be something that is easy or straightforward, such as a task that doesn't require much thought or doesn't take too long to complete. Some other antonyms for most toilful might include words like simple, easy, effortless, uncomplicated, and smooth-sailing. It's important to note that the opposite of most toilful will depend on the context in which it is used.