The phrase "out of house and home" is an idiom that means to be left with nothing, or to be completely without resources. There are several synonyms for this phrase that convey a similar sentiment. For instance, one might say they are "penniless", "broke", or "bankrupt". Alternatively, they could be "destitute", "impoverished", or "deprived". Other possible synonyms include "homeless", "abandoned", or "dispossessed". Regardless of the specific term used, all of these synonyms suggest a state of extreme poverty or destitution, where one has lost everything they previously had.