Puckered up refers to a facial expression characterized by tightly pressed lips and wrinkles around the mouth. It is a common gesture that conveys a range of emotions from disapproval to surprise and discomfort. There are numerous synonyms for puckered up, including pursed, tightened, compressed, crinkled, squeezed, contracted, and scrunched. These words all capture the essence of the facial expression and can be used interchangeably in various contexts. Puckered up is a universal expression that is understood by people of all cultures and languages. Whether in joy or pain, the familiar pucker always speaks volumes.