Scrapie Associated Fibrils (SAFs) are pathological protein aggregates found in the brain tissues of animals affected by scrapie, a prion disease that predominantly affects sheep. These abnormal structures are composed of misfolded prion proteins. Synonyms for SAFs include "amyloid fibrils", as they share certain characteristics with amyloid plaques found in other neurodegenerative diseases like Alzheimer's. Additionally, they can be referred to as "prion plaques" or "prion aggregates" due to their association with the misfolded prion proteins. Understanding and studying these SAFs is crucial in revealing the underlying mechanisms of prion diseases and developing effective therapeutic strategies to combat them.