Antonyms for the phrase "takes up residence" include "moves out," "vacates," "evacuates," and "departs." Whenever someone takes up residence in a new place, they're essentially moving in and establishing a permanent living arrangement. On the other hand, when they move out, vacate, or evacuate, they're leaving that same living arrangement behind. Departing, meanwhile, refers to leaving a particular location, whether or not there was ever any residence involved. By knowing the antonyms for "takes up residence," you'll be able to more clearly describe the actions of people moving in and out of different living arrangements.