The phrase "are pissed off" conveys a sense of anger or annoyance that may be too harsh or vulgar for certain situations. Alternatives to this phrase could include "are frustrated," "are irked," "are displeased," or "are annoyed." Other options that might suit different contexts include "are upset," "are bothered," "are aggravated," or "are disgusted." Depending on the level of intensity required, there are countless synonyms that could be used in place of "are pissed off," such as "are incensed," "are enraged," "are livid," or "are seething." The choice of synonym should depend on the speaker's intended tone and the audience's expectations.