What are the opposite words for have no effect on?

The polar opposite of "have no effect on" (meaning the inability to affect something) is "have a significant effect on" (meaning a notable influence on something). Other antonyms for "have no effect on" include "affect greatly," "significantly alter," "profoundly change," "impact," and "transform." These terms convey an ability to influence, modify, or reshape a situation or condition, in contrast to having no effect at all. It is essential to grasp these opposing expressions in writing to communicate precise and accurate information about the exact nature of the relationship between two things.