Calluses are thickened areas of the skin that form as a protective response to repeated friction or pressure on a particular area of the body. The opposite of calluses is tender skin, which is soft and sensitive, lacking any hard or thickened areas. Tender skin is not accustomed to friction or pressure and does not have any protective layer. Another antonym for calluses is smooth skin that is free from any hard or rough patches. Smooth skin is delicate and soft to the touch, making it a desirable trait for aesthetic purposes. Other antonyms for calluses may include gentle, delicate, supple, vulnerable, and pliable.