The term "cholangiocyte" refers to a specialized epithelial cell that lines the intrahepatic bile ducts. Synonyms for cholangiocyte include biliary epithelial cells, cholangial cells, and bile duct cells. These cells are important as they contribute to the process of bile formation, secretion, and flow. In addition to their physiological functions, cholangiocytes can undergo molecular changes that lead to the development of liver diseases, such as cholangiopathies and cholangiocarcinoma. Hence, understanding the intricacies of cholangiocyte biology has significant implications for the diagnosis, prevention, and treatment of liver diseases.