Chromatography is a laboratory technique utilized to separate components in a mixture by passing it over a stationary phase, causing each component to interact differently with the stationary phase and move at different rates. In blood processing, chromatography is commonly used to identify and analyze various biomolecules, such as proteins and sugars, to diagnose and monitor diseases. Synonyms for chromatography in blood processing include affinity chromatography, ion exchange chromatography, and size exclusion chromatography. Each methodology has unique benefits and limitations, which depend on the specific characteristics of the samples being analyzed. Therefore, selecting the appropriate chromatography method is crucial for accurately identifying and quantifying biomolecules in blood samples.