High-grade serous carcinoma (HGSC) is a type of ovarian cancer that typically occurs in postmenopausal women. Synonyms for HGSC include serous ovarian cancer, ovarian serous carcinoma, and high-grade serous ovarian carcinoma. It is a very aggressive form of cancer and is often diagnosed in advanced stages. Treatment for HGSC typically involves surgery to remove the tumors and chemotherapy to kill any remaining cancer cells. Early detection through regular gynecological exams and symptom recognition is crucial for better prognosis. Understanding the various synonyms for HGSC can help patients and their loved ones better understand and communicate about their diagnosis and treatment options.