Santa Maria is a term which can have several synonyms. The most popular synonym for Santa Maria is Holy Mary. Other synonyms include the Virgin Mary, Mother of God, Immaculate Conception and Queen of Heaven. These terms are often used in religious contexts and show reverence to the mother of Jesus Christ. Santa Maria is a Spanish term that directly translates to Saint Mary. It is typically used to refer to the city of Santa Maria in California or the ship that Christopher Columbus used on his first voyage to America. In summary, Santa Maria can be exchanged with synonyms such as Holy Mary, Mother of God, Immaculate Conception, Queen of Heaven or Saint Mary.