The word "un-wholesomely" refers to something that is detrimental to one's health or well-being. There are several synonyms that can be used to express this meaning, such as unhealthily, deleteriously, injuriously, and noxiously. These words all convey the notion that something is harmful or detrimental to one's physical or mental state. Other synonyms for "un-wholesomely" might include "toxic," "dangerous," "unhealthy," "hazardous," or "insalubrious." Each of these words can be used to describe a situation or substance that poses a threat to an individual's health. In contrast, antonyms for "un-wholesomely" might include "healthily," "beneficially," "nourishingly," or "salubriously." These words all suggest something that is good for one's health or well-being.