The phrase "make muck of" refers to ruining or destroying something, and there are a variety of synonyms that can be used to convey a similar meaning. Some options include "wreck," "ruin," "demolish," "devastate," "dismantle," "undo," "spoil," "taint," "scuttle," "undo," "disfigure," and "mangle." Each of these words conveys a sense of destruction or harm, and can be used in a variety of contexts, from describing physical damage to discussing the impact of negative emotions or actions on a person's life or relationships. While slightly different in nuance, each synonym can be used effectively to convey the idea of making a mess or destroying something.