When it comes to describing a thick slice, there are a few synonyms that can be used to add variety to your descriptions. One alternative to thick slice is "chunk," which implies a larger, more substantial piece of something. Another option is "slab," which brings to mind an image of a thick, flat piece. You could also use "hunk," which emphasizes the size and weight of the slice. For foods like bread or cake, "loaf slice" or "cake wedge" could be used to specify the shape of the slice. No matter which synonym you choose, using variations can help keep your writing interesting and engaging.