The word "downfallen" refers to someone or something that has experienced a significant decline, usually due to some kind of failure or setback. There are a number of synonyms that can be used to convey this sense of decline or defeat, including "fallen," "collapsed," "ruined," "destroyed," "demolished," "decimated," "devastated," "wrecked," "shattered," and "overthrown." Each of these words emphasizes the sense of loss or failure that characterizes a downfall, whether it is a personal or professional one. Whether describing a career, a reputation, or a personal relationship, these words allow us to express the full range of emotions associated with defeat and loss.