Holy Joe is a term originally used to describe a pious or sanctimonious person. However, it can be seen as derogatory or offensive in some contexts. To avoid offending anyone, it's useful to know some synonyms for this phrase. Some words that can be used instead of Holy Joe include devout, righteous, prayerful, religious, godly, reverent, zealous, faithful, pure, and spiritual. These words convey similar meanings without the negative connotations of the term Holy Joe. Whether in written or spoken communication, choosing the right words can show respect and convey the intended message more effectively.