The term "be-friend" means to establish a friendly relationship with someone. Its antonyms include words such as "alienate," "estranged," "distance," "disaffect," "isolate," "separate," "unfriend," "unfriendliness," and "unfriendship." These words indicate the opposite meaning of "be-friend." When a person is alienated, estranged, isolated, or separated, they are no longer attached to others in a friendly manner, and therefore they become indifferent to them. It is important to understand the antonyms of "be-friend" since it helps to know how to make a lasting connection with other people.