Fretfully is an adjective that describes a state of agitation or uneasiness. Some synonyms for fretfully include anxiously, worriedly, nervously, agitatedly, restlessly, and jittery. These words convey a sense of apprehension or nervousness, and are often used to describe a person who is experiencing anxiety or concern. Fretfully can also be replaced with the word distressed, which implies a deeper level of discomfort or anguish. Other synonyms for fretfully include twitchily, nervily, and flustered, which also describe a sense of unease or restlessness. These words can be useful when writing about characters or situations that involve tension or anxiety.